BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, Volume 1, Drug Discovery, 6th Edition

Book Summary of Burger's Medicinal Chemistry And Drug Discovery, Volume 1, Drug Discovery, 6th Edition

Product description

"An essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research."

-Journal of Medicinal Chemistry on the Fifth Edition 

This new edition of Dr. Alfred Burger's internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred in the field, this latest edition brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery now in use around the world. 

This Sixth Edition of Burger's Medicinal Chemistry and Drug Discovery has been expanded to six volumes: 

Volume 1: Drug Discovery

Volume 2: Drug Discovery and Drug Development

Volume 3: Cardiovascular Agents and Endocrines

Volume 4: Autocoids, Diagnostics, and Drugs from New Biology

Volume 5: Chemotherapeutic Agents

Volume 6: Nervous System Agents 

This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.

Next volume will be in next post

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Modern Drug Synthesis

Modern Drug Synthesis.

By Jie Jack Li, Douglas S. Johnson

• Publisher: Wiley
• Number Of Pages: 355
• Publication Date: 2010-08-09
• ISBN-10 / ASIN: 0470525835
• ISBN-13 / EAN: 9780470525838

Product Description:

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

The all–inclusive book on the cutting–edge science driving the medicinal chemistry of the latest drugs

The successor to the editors′ two highly acclaimed works on drug synthesis, Contemporary Drug Synthesis and The Art of Drug Synthesis, this book provides refocused and extensive new coverage detailing how chemistry, biology, and pharmacokinetics integrate to spearhead successful medical findings. Modern Drug Synthesis carries on the mission of delivering the most up–to–date developments unfolding in this rapidly evolving field by placing a stronger emphasis on medicinal chemistry and pharmacology, in addition to drug synthesis. Other highlights include:

• Chapters are logically divided into categories such as background of disease area, pharmacology, SAR (structure–activity relationships), pharmacokinetics and drug metabolism, efficacy and safety, and synthesis
• Expert analysis of the pros and cons of different synthetic routes
• A step–by–step breakdown of today′s drug discovery process for professionals and students
• Supporting case studies in each chapter

Modern Drug Synthesis shows that whether drug synthesis is in early development or the process stage, the ability to design elegant and economical synthetic routes is often a major factor making a drug a commercial winner. Easy to follow and stacked with valuable information on the present and future direction of medicinal chemistry, Modern Drug Synthesis is the one guide that paints a clear and complete picture of this complex subject.

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Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing

Biocatalysis for the Pharmaceutical Industry: Discovery, Development, and Manufacturing.

By Junhua Tao, Guo-Qiang Lin, Andreas Liese

• Publisher: Wiley
• Number Of Pages: 250
• Publication Date: 2008-10-31
• ISBN-10 / ASIN: 0470823143
• ISBN-13 / EAN: 9780470823149

Product Description:

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field.

• Covers a wide range of topics in a systematic manner with an emphasis on industrial applications
• Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering
• Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs
• Highlights the impact of biocatalysis on green chemistry
• Contains numerous graphics to illustrate concepts and techniques

Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

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Introduction to Medicinal Chemistry

Introduction to Medicinal Chemistry: How Drugs Act and Why by: Alex Gringauz

Publisher: Wiley-VCH | ISBN: 0471185450 | 1996-12-27 | Pages: 736 | DJVU | 23 MB

This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents.

Basic Considerations of Drug Activity.

Mechanisms of Drug Action.

Drug Metabolism and Inactivation.

Anticancer Drugs and Their Mechanism of Action.

Analgetics and Nonsteroidal Antiinflammatory Agents.

Antimicrobial Drugs I. Antimicrobial Drugs II.

Drugs Affecting Cholinergic Mechanisms.

Drugs Affecting Adrenergic Mechanisms.

Drugs and the Cardiovascular Diseases.

Drugs and the Cardiovascular Diseases II.

Psychoactive Drugs--Chemotherapy of the Mind.

Histamine Antagonists and Local Anesthetics.

Steroids.

New Developments and New Problems.

Index.

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Pharmaceutical Packaging Handbook

Pharmaceutical Packaging Handbook

Informa Healthcare | 2009 | ISBN: 1587161516 | 350 pages | PDF | 14 MB

A complete overview of the role that packaging plays in the development and delivery of pharmaceuticals and medical devices. Including a thorough examination of the industry in size and scope, this source gives an introduction drug dosage forms, vaccines, biologically produced products, and medical foods to the reader.

Pharmaceutical Packaging Handbook is the most complete and straightforward text on the market today and also lists information in an easy to follow fashion, making it a complete stand-alone reference for anyone working in the pharmaceutical industry.

Pharmaceutical Packaging Handbook:

discusses how packaging is designed and integrated into the product development cycle has an overview of the regulatory environment procedures provides the reader with a basic introduction into key aspects of navigating the regulations describing the materials used to package pharmaceuticals, including glass, metal, plastics, flexible films, rubbers and elastomers comments on some new hybrids used for packaging, with a short introduction to plastics, their makeup, and typical uses in packaging explores the processing techniques used with the materials to produce pharmaceutical containers and some of the strengths and weaknesses of the processes used for container fabrication introduces the reader to retort, aseptic, gas, and radiation sterilization of product discusses labeling and design for pharmaceuticals including how labels are produced, materials used, and production techniques

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Pharmaceutics: The Science of Dosage Form Design by Aulton

 

Pharmaceutics: The Science of Dosage Form Design by Aulton

A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. 'Pharmaceutics' in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture, and the elimination of micro-organisms from the products. This books encompasses all those areas and pays particular attention to the design of dosage forms and their manufacture.

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Stockley's Drug Interactions 2009 Pocket Companion

Karen Baxter, Mildred Davis, Samuel Driver, Rebecca E. Garner, C. Rhoda Lee, "Stockley's Drug Interactions 2009 Pocket Companion"
Pharmaceutical Press | 2009 | ISBN: 0853697957 | 459 pages | PDF | 2,4 MB

This new edition continues to provide the busy health care professional with a small and conveniently sized quick reference "Stockley" text. "Stockley's Drug Interactions Pocket Companion 2009" draws on the wealth of clinically evaluated, evidence-based information on drug-drug, drug-herb and drug-food interactions that is presented in the full reference work, "Stockley's Drug Interactions".
Stockley’s Drug Interactions Pocket Companion 2009 provides busy healthcare professionals with a small and conveniently sized, quick-reference Stockley text. It draws on the wealth of clinically evaluated, evidence-based information on drug-drug, drug-herb and drug-food interactions that is presented in the full reference work, Stockley’s Drug Interactions .: Follows the familiar format of the Stockley products; Includes over 1500 interaction monographs pertaining to specific drugs or drug groups; Arranged alphabetically for ease of searching; Contains a comprehensive index; Easy-to-use severity rating symbols offer guidance to the user on the clinical significance of the interaction; An essential clinical reference for physicians, pharmacists, nurses and other healthcare professionals. Due to the wide international appeal of this content, the text is now translated into Spanish, Italian and Japanese.

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Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry.
Publisher: Wiley-VCH | 2010 | PDF | 388 pages | ISBN: 3527324186 | 5.8Mb

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

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Modern Industrial Microbiology and Biotechnology

Nduka Okafor, “Modern Industrial Microbiology and Biotechnology

Science Publishers | 2007-03-30 | ISBN: 1578084342 | 539 pages | PDF | 4 MB

This book is directed towards undergraduates and beginning graduate students in microbiology, food science and chemical engineering. Those studying pharmacy, biochemistry and general biology will find it of interest. The section on waste disposal will be of interest to civil engineering and public health students and practitioners. For the benefit of those students who may be unfamiliar with the basic biological assumptions underlying industrial microbiology, such as students of chemical and civil engineering, elements of biology and microbiology are introduced. The new elements which have necessitated the shift in paradigm in industrial microbiology such as bioinformatics, genomics, proteomics, site-directed mutation, metabolic engineering, the human genome project and others are also introduced and their relevance to industrial microbiology and biotechnology indicated. As many references as space will permit are included. The various applications of industrial microbiology are covered broadly, and the chapters are grouped to reflect these applications. The emphasis throughout, however, is on the physiological, biochemical principles, and where possible, the genomic principles behind these applications.

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