Pharma downloads: 3-2 syllabus

Showing posts with label 3-2 syllabus. Show all posts

8/3/10

PHARMACEUTICAL ANALYSIS - II (PRACTCAL)

5:14 AM Sri No comments

1. Separation of plant materials by column chromatography
2. Separation and identification of flavanoids/sulphonamides by paper chromatography
3. Separation and identification of sulphonamides by paper chromatography
4. Separation and identification of amino acids by TLC methods
5. Separation and identification of barbiturates by TLC methods
6. Determination of λ max, (KMnO4 and methylene blue solutions)
7. Demonstration experiments in HPLC and GLC
8. Assay of sulphadiazine tablets by visible spectrophotometry
9. Assay of sulphadiazine tablets by UV spectrophotometry
10. Demonstration experiments in IR spectrometry including interpretation of given spectra.
11. Fluorimetric estimation of quinine sulphate in formulations
12. Fluorimetric estimation of riboflavin in formulations
13. Flame photometric estimation of sodium and potassium ions
14. Potentiometric analysis a) Determination of pH of two solutions b) Titration of strong acid against strong base c) Titration of strong base against weak acid d) Simultaneous determination of strong acid and weak acid in a mixture e) Potentiometric assay of any two formulations from I.P.
15. Conductometric titration of NaOH with HCl
16. Polarographic estimation of drug official in I.P.
17. Determination of concentration of sugar solution by polarimetry
18. Determination of critical micellar concentration (butyric acid in water using abbe refractometer)
19. Demonstration experiments in detection of polymorphism and pseudo polymorphism in pharmaceuticals by DTA and DSC
20. Assay of an ointment and cream official in I.P.
21. Complete testing and assay of any two drugs as per I.P. monograph.

Reference books:
1. A text book of pharmaceutical analysis by K.A.Connors (John Wiley)

PHARMACEUTICAL ANALYSIS - II (THEORY)

5:12 AM Sri 1 comment

Physiochemical chemical aspects of analytical chemistry with special reference to pharmaceutical analysis.

Chromatographic methods-1: Principles, theories, instrumentation and applications involved in a) column chromatography b) Paper chromotography c) Thin layer chromatography and HPTLC d) Ion exchange and gel filtration techniques
Chromatographic methods-II: Principles, theories, instrumentation and applications involved in a) Gas chromatography (GC) b) High performance liquid chromatography (HPLC)

Spectrophotometric analysis: A discussion of basic principles including interaction of matter with electro-magnetic radiation, absorption, emission, luminescence and scattering phenomena, units of measurement and definition of terms: a) absorptiometry: quantitative consideration of absorption phenomena including Beer and Lambert's laws and their mathematical expression, deviations from the laws and methods used in absorption spectrophotometry (visible, UV and IR) including sources, monochromators, detectors, preparation of calibration curves and pharmaceutical applications. Sources of errors and their correction and validation of spectrophotometric methods. B) Basic principles, equipment and methods used and pharmaceutical applications of flame photometry, photofluorimetry, turbidimetry and nephlometry.

Electrochemical analysis: A discussion of basic principles involved in electrochemical analysis, electrochemical cells and half-cells, electrodes, electrode reactions and electrode potentials: a) Potentiometry: basic principles involved in measurement of EMF and pH, Nernst equation, typical equipment and their construction, factors influencing EMF of cells, portable, stationary and online equipment for pH measurement, applications b) Potentiometric titrations including principles involved, methods for detection of end point including dead stop mend point, applications in neutralization, redox and precipitation titrations, equipment used, exploration of titration curves obtained with acids and bases of different strength and mixture of acids. c) Conductometric titrations: basic principles, titrations, equipment and applications.
d) Polarography: basic principles, titrations, equipment and applications in qualitative and quantitative analysis. e) amperometric titrations: basic principles, titrations, equipment and applications.
Basic principles, definition of terms, equipment and their working and applications of NMR and Mass spectrometry. Thermal methods of analyses and radioimmunoassay.

Textbooks:
1. Practical pharmacology

chemistry by A.H.Beckett and J.B.Stenlake
2. Indian Pharmacopoeia

Reference books:
1. Pharmaceutical chemistry by L.G.Chattern (Marcel Dekker)
2. A text book of pharmaceutical analysis by K.A.Connors (John Willey)
3. Pharmaceutical analysis- modern methods by J.W.Munson (Marcel Dekker)
4. Instrumental methods of analysis by Willard, Merritt, Dean and Settle (CBS Publishers)
5. Text book of analytical chemistry, by Y.Anjaneyulu, K.Chandra sekhar and Valli manickam.
6. Introduction to instrumental analysis by Robert D.Braun published by pharma book syndicate.

INDUSTRIAL PHARMACY & COSMETIC TECHNOLOGY PRACTICAL

5:11 AM Sri No comments

Formulation, preparation and qualilty control of pharmaceutical products (25) covering dosage forms listed in theory. The number of products under each category is as follows:

Tablets-6, Liquid orals-4, Emulsions-3, Capsules-2, Parentals-4, SR tablets-2, Cosmetics-4

Textbooks:
1. The theory and practice of Industrial Pharmacy by Leon Lachman, H.A.Lieberman and Joseph L.Kanig.
2. Pharmaceutics, The science of Dosage form design, edited by Michael E.Aulton
3. Science and technology of Cosmetics by Sagarin.
4. Remington's Practice of pharmaceutical sciences.

INDUSTRIAL PHARMACY & COSMETIC TECHNOLOGY

5:10 AM Sri 1 comment

I. Pre-formulation: Objectives-Protocols-Physical, chemical, micrometric studies in preoformulation, stability considerations, drug-excipient compatibility.

II. Formulation Decelopment: Factors involved, Case studies: Formulation of (i) An antacid product (ii) An ampicillin product for paediatric use (iii) An antibacterial product for a child (iv) Pain balm (v) An anti inflammatory gel.

III. A study of the formulation, process and equipment used in the large scale manufacture, evaluation, and quality control of the following dosage forms.
(i) Suspensions (ii) Emulsions (iii) Liquid orals (Syrups and Elixirs).

IV. (i) Tablets (ii) Tablet coating - sugar, film and enteric coating (iii) Capsules - hard and soft.

V. (i) Parentals (ii) Other sterile products - eye ointments, eye drops.

VI. (i) Sustained re;ease products (ii) Microencapsulation and microcapsules (iii) Aerosol preparations.

VII. Formulation and preparation of the following Cosmetics - Hand lotions and creams, face powders, baby and bath powders, dentifrices, shampoo, lipstick, shaving preparations and hair dyes and creams, skin creams.

PHARMACOLOGY - I PRACTICAL

5:09 AM Sri No comments

1. Excretion of drugs in urine, sweat, saliva in humans.
2. Involvement of acetylcholine in ciliary movement of frog's oesophagus.
3. Drug action on the eye of rabbit-miotics and mydriatics.
4. Drug antagonism with pilocarpine and atropine in rabbits.
5. Straub test and analgesia with morphine in the mice.
6. Drug action on insitu rectum of frog.
7. Drug action on intact frog heart.
8. Action of acetylcholine and nicotine on the rectus abdominis muscle of frog.
9. Dose response curve (DRC) with acetylcholine on rectus abdominis muscle of frog.
10. Potentiation of acetylcholine response but not of nicotine by eserine on rectus abdominis muscle of frog.
11. Inhibition of acetylcholine response by caure/procaine/quinidine/pethidine on rectus abdominis muscle of frog.
12. different stages of general anaesthesia using ether in mice.
13. Effect of ions on isolated perfused frog heart.
14. Effect of digoxin on normal and hypodynamic heart.

PHARMACOLOGY - I THEORY

5:08 AM Sri No comments

1. General pharmacology: How do drugs act? Receptor and non-receptor mechanisms of drug action. Brief introduction to structure activity relationship. Normal and unwanted activities of drugs. Factors influencing drug action.

2. Drugs acting on central nervous system: Central depressants-ethyl alcohol, general anesthetics, basal narcotics, hypnotics, analgesic hypnotics, anxiolytics, antipyretic analgesics.
CNS stimulants and analeptics.
Psychopharmacological agents: Neuroleptics, antidepressants, anxiolytics, hallucinogens.
Habit formation drugs of addiction.
3. Drugs acting on Autonomic Nervous system: Parasympathomimetic and parasympathetic blocking agents. Sympathomimetic and sympathetic blocking agents. Ganglionic stimulants and blockers, skeletal muscle relaxants.
4. Drugs acting on cardiovascular system: Coagulants, anticoagulants, Drugs acting on blood forming organs, antihypertensive agents, vasodialators, antianginal agents, antiarrhythmics, cardiotonics, plasma substitutes, antihyperlipidemic agents.
5. Drug acting on the Kidney: Diuretics, antidiuretics, drugs useful in urinary tract infections.

Text Books:
1. Textbook of Pharmacology by Rang and Dale.
2. Essentials of Medical Pharmacology - KD Tripathi.
3. Lippincoort's illustrated pharmacology.
Pharmacology and pharmacotherapeutics by Satoshkar and Bandarkar.

Reference Books:
1. Pharmacological basis of Therapeutics by Goodman and Gillman.
2. Text book of clinical pharmacology - Bertram.C.Katzung

FORENSIC PHARMACY

5:06 AM Sri No comments

Evolution of pharmacy and drug legislation in India. A study of the following acts with upto date amendments.

Pharnacy Act
Drugs and Cosmetic Act and Rules
Narcotic Drugs and Psychotropic Substances Act (1986)
Drugs and Magic Remedies Act
Drugs (price control) Act
Medicinal and Toilet Preparation (Excise duties) Act and Rules.
Patents Act and Intellectual Property Rights
Medical Termination of Pregnancy Act
Code of Pharmaceutical Ethics

Suggested Books:
1. Original laws Published by Government of India
2. Forensic Pharmacy by B.M.Mithal
3. Laws of drugs in India - Hussain
4. Intellectual Property Law by R.K.Nagarajan
5. Text book of forensic pharmacy by C.K.Kokate and S.B.Gokhale published by pharma book syndicate